| Gene Information | |
|---|---|
| Gene Name | PRKG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 762 |
| Protein Names | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) |
| Target Name | cgmp-dependent protein kinase 2 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000138669 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13237 |
| Gene Card | PRKG2 |
| Uniprot ID | Q13237 |
| Pfam | PF00027; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.768970562) |
| Ortholog in Animals | Alpaca_ PRKG2 ( ortholog_one2one ) Dog_ PRKG2 ( ortholog_one2one ) GuineaPig_ PRKG2 ( ortholog_one2one ) Macaque_ PRKG2 ( ortholog_one2one ) Mouse_ Prkg2 ( ortholog_one2one ) Pig_ PRKG2 ( ortholog_one2one ) Rat_ Prkg2 ( ortholog_one2one ) Rabbit_ PRKG2 ( ortholog_one2one ) |
| Ohnologs | PRKG1 |
| Paralogs | PRKX, PRKACB, PRKACG, PRKG1, PRKACA |
| Tissue | duodenum, prostate, small.intestine |
| Tissue Specificity | Highly concentrated in brain, lung and intestinal mucosa. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5BV6 (X-ray 1.94A ) 5C6C (X-ray 2.05A ) 5C8W (X-ray 1.80A ) 5JIX (X-ray 1.47A ) 5JIZ (X-ray 1.50A ) 6BQ8 (Other 2.00A ) |
| DBSNP | rs34956759 rs34616910 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:8636133}; Lipid-anchor {ECO:0000269|PubMed:8636133}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |