| Gene Information | |
|---|---|
| Gene Name | BAG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 345 |
| Protein Names | BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1) |
| Target Name | bag family molecular chaperone regulator 1 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000107262 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q99933 |
| Gene Card | BAG1 |
| Uniprot ID | Q99933 |
| Pfam | PF02179; PF00240 |
| In ASD | no |
| Allosteric Prediction | yes (0.500412478) |
| Ortholog in Animals | Alpaca_ BAG1 ( ortholog_one2one ) Dog_ BAG1 ( ortholog_one2one ) Macaque_ BAG1 ( ortholog_one2one ) Mouse_ Bag1 ( ortholog_one2one ) Pig_ BAG1 ( ortholog_one2one ) Rat_ Bag1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level). {ECO:0000269|PubMed:9679980}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1HX1 (X-ray 1.90A ) 1WXV (NMR - ) 3FZF (X-ray 2.20A ) 3FZH (X-ray 2.00A ) 3FZK (X-ray 2.10A ) 3FZL (X-ray 2.20A ) 3FZM (X-ray 2.30A ) 3LDQ (X-ray 1.90A ) 3M3Z (X-ray 2.10A ) 5AQF (X-ray 1.88A ) 5AQG (X-ray 2.24A ) 5AQH (X-ray 2.00A ) 5AQI (X-ray 1.98A ) 5AQJ (X-ray 1.96A ) 5AQK (X-ray 2.09A ) 5AQL (X-ray 1.69A ) 5AQM (X-ray 1.63A ) 5AQN (X-ray 2.45A ) 5AQO (X-ray 2.12A ) 5AQP (X-ray 2.08A ) 5AQQ (X-ray 2.72A ) 5AQR (X-ray 1.91A ) 5AQS (X-ray 2.00A ) 5AQT (X-ray 1.90A ) 5AQU (X-ray 1.92A ) 5AQV (X-ray 1.75A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus.; [Isoform 2]: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock.; [Isoform 4]: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria. |
| Mouse PG classification | NA |
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