| Gene Information | |
|---|---|
| Gene Name | BAF |
| Organism | Homo sapiens (Human) |
| Gene Length | 89 |
| Protein Names | Barrier-to-autointegration factor (Breakpoint cluster region protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O75531 |
| Gene Card | BANF1 |
| Uniprot ID | O75531 |
| Pfam | PF02961 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in colon, brain, heart, kidney, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen and testis. Not detected in thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:9740667}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003847(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1CI4 (X-ray 1.90A ) 1QCK (NMR - ) 2BZF (X-ray 2.87A ) 2EZX (NMR - ) 2EZY (NMR - ) 2EZZ (NMR - ) 2ODG (NMR - ) 6GHD (X-ray 2.10A ) 6RPR (X-ray 2.26A ) 6UNT (X-ray 1.75A ) 6URE (X-ray 1.65A ) 6URJ (X-ray 1.65A ) 6URK (X-ray 1.86A ) 6URL (X-ray 1.72A ) 6URN (X-ray 1.68A ) 6URR (X-ray 1.80A ) 6URZ (X-ray 1.65A ) 6US0 (X-ray 1.65A ) 6US1 (X-ray 1.65A ) 6US7 (X-ray 1.65A ) 6USB (X-ray 1.68A ) 6USD (X-ray 1.65A ) 6USI (X-ray 1.65A ) 7ABM (X-ray 3.00A ) 7NDY (X-ray 1.44A ) 7Z21 (X-ray 1.63A ) |
| DBSNP | rs387906871 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18005698, ECO:0000269|PubMed:24600006}. Chromosome {ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:28841419, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32792394}. Nucleus envelope {ECO:0000269|PubMed:24600006}. Cytoplasm {ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18005698, ECO:0000269|PubMed:24600006}. Note=Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase (PubMed:16495336, PubMed:24600006). The phosphorylated form (by VRK1) shows a cytoplasmic localization whereas the unphosphorylated form locates almost exclusively in the nucleus (PubMed:16495336, PubMed:24600006). May be included in HIV-1 virions via its interaction with viral GAG polyprotein (PubMed:14645565). {ECO:0000269|PubMed:14645565, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:24600006}. |
| Mouse PG classification | NA |
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