Gene Information
Gene NameBACE2
OrganismHomo sapiens (Human)
Gene Length518
Protein NamesBeta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase)
Target Namebeta-site app-cleaving enzyme 2
Target TypeClinical trial target
Gene Age544 ( ENSG00000182240 )
Evolutionary StageEukaryota
AlphaFoldDBQ9Y5Z0
Gene CardBACE2
Uniprot IDQ9Y5Z0
PfamPF00026
In ASDno
Allosteric Predictionyes (0.194297663)
Ortholog in AnimalsAlpaca_ BACE2 ( ortholog_one2one )
Dog_ BACE2 ( ortholog_one2one )
GuineaPig_ BACE2 ( ortholog_one2one )
Macaque_ BACE2 ( ortholog_one2one )
Mouse_ Bace2 ( ortholog_one2one )
Rat_ Bace2 ( ortholog_one2one )
Rabbit_ BACE2 ( ortholog_one2one )
OhnologsBACE1
ParalogsPGC, REN, CTSE, BACE1, NAPSA, CTSD, PGA5, PGA4, PGA3
TissueNA
Tissue SpecificityBrain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:10683441, ECO:0000269|PubMed:10749877, ECO:0000269|PubMed:10838186, ECO:0000269|PubMed:10965118, ECO:0000269|PubMed:11083922}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2EWY  (X-ray  3.10A  )  3ZKG  (X-ray  1.90A  )  3ZKI  (X-ray  2.40A  )  3ZKM  (X-ray  1.85A  )  3ZKN  (X-ray  2.00A  )  3ZKQ  (X-ray  1.51A  )  3ZKS  (X-ray  2.11A  )  3ZKX  (X-ray  2.37A  )  3ZL7  (X-ray  3.20A  )  3ZLQ  (X-ray  2.10A  )  4BEL  (X-ray  1.85A  )  4BFB  (X-ray  2.21A  )  6JSZ  (X-ray  1.53A  )  6UJ0  (X-ray  2.15A  )  6UJ1  (X-ray  3.03A  )  7D5B  (X-ray  1.31A  )  7D5U  (X-ray  2.04A  )  7F1G  (X-ray  1.50A  )  7N4N  (X-ray  1.41A  ) 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:21907142};
Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:11423558}. Endoplasmic reticulum. Endosome. Melanosome {ECO:0000269|PubMed:23754390}. Note=Colocalizes with PMEL in stage I and II melanosomes. {ECO:0000269|PubMed:23754390}.
Mouse PG classificationNA
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