| Gene Information | |
|---|---|
| Gene Name | B7H1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 290 |
| Protein Names | Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NZQ7 |
| Gene Card | CD274 |
| Uniprot ID | Q9NZQ7 |
| Pfam | PF08205; PF07686 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3BIK (X-ray 2.65A ) 3BIS (X-ray 2.64A ) 3FN3 (X-ray 2.70A ) 3SBW (X-ray 2.28A ) 4Z18 (X-ray 1.95A ) 4ZQK (X-ray 2.45A ) 5C3T (X-ray 1.80A ) 5GGT (X-ray 2.80A ) 5GRJ (X-ray 3.21A ) 5IUS (X-ray 2.89A ) 5J89 (X-ray 2.20A ) 5J8O (X-ray 2.30A ) 5JDR (X-ray 2.70A ) 5JDS (X-ray 1.70A ) 5N2D (X-ray 2.35A ) 5N2F (X-ray 1.70A ) 5NIU (X-ray 2.01A ) 5O45 (X-ray 0.99A ) 5O4Y (X-ray 2.30A ) 5X8L (X-ray 3.10A ) 5X8M (X-ray 2.66A ) 5XJ4 (X-ray 2.30A ) 5XXY (X-ray 2.90A ) 6L8R (NMR - ) 6NM7 (X-ray 2.43A ) 6NM8 (X-ray 2.79A ) 6NNV (X-ray 1.92A ) 6NOJ (X-ray 2.33A ) 6NOS (X-ray 2.70A ) 6NP9 (X-ray 1.27A ) 6PV9 (X-ray 2.00A ) 6R3K (X-ray 2.20A ) 6RPG (X-ray 2.70A ) 6VQN (X-ray 2.49A ) 6YCR (X-ray 1.54A ) 7BEA (X-ray 2.45A ) 7C88 (X-ray 2.00A ) 7CZD (X-ray 1.64A ) 7DCV (NMR - ) 7DY7 (X-ray 2.42A ) 7NLD (X-ray 2.30A ) 7OUN (X-ray 1.90A ) 7SJQ (X-ray 2.00A ) 7TPS (X-ray 3.15A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:28813417}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:28813417}; Single-pass type I membrane protein {ECO:0000255}. Note=Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation. {ECO:0000269|PubMed:28813417}.; [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15780196}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 2]: Endomembrane system {ECO:0000269|PubMed:15780196}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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