Gene Information
Gene NameB2AR
OrganismHomo sapiens (Human)
Gene Length413
Protein NamesBeta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP07550
Gene CardADRB2
Uniprot IDP07550
PfamPF00001
In ASDyes
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002865(Rat);0.011765(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1GQ4  (X-ray  1.90A  2R4R  (X-ray  3.40A  2R4S  (X-ray  3.40A  2RH1  (X-ray  2.40A  3D4S  (X-ray  2.80A  3KJ6  (X-ray  3.40A  3NY8  (X-ray  2.84A  3NY9  (X-ray  2.84A  3NYA  (X-ray  3.16A  3P0G  (X-ray  3.50A  3PDS  (X-ray  3.50A  3SN6  (X-ray  3.20A  4GBR  (X-ray  3.99A  4LDE  (X-ray  2.79A  4LDL  (X-ray  3.10A  4LDO  (X-ray  3.20A  4QKX  (X-ray  3.30A  5D5A  (X-ray  2.48A  5D5B  (X-ray  3.80A  5D6L  (X-ray  3.20A  5JQH  (X-ray  3.20A  5X7D  (X-ray  2.70A  6E67  (X-ray  3.70A  6KR8  (NMR  6MXT  (X-ray  2.96A  6N48  (X-ray  3.20A  6NI3  (EM  3.80A  6OBA  (X-ray  3.10A  6PRZ  (X-ray  2.80A  6PS0  (X-ray  3.40A  6PS1  (X-ray  3.20A  6PS2  (X-ray  2.40A  6PS3  (X-ray  2.50A  6PS4  (X-ray  2.60A  6PS5  (X-ray  2.90A  6PS6  (X-ray  2.70A  7BZ2  (EM  3.82A  7DHI  (EM  3.26A  7DHR  (EM  3.80A 
DBSNP rs33973603  rs1042713  rs1042714  rs990810566  rs1800888  rs3729943  rs771585355 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23166351, ECO:0000269|PubMed:25220262, ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137};
Multi-pass membrane protein {ECO:0000269|PubMed:19584355}. Early endosome {ECO:0000269|PubMed:20559325}. Golgi apparatus {ECO:0000269|PubMed:27481942}. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). {ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:27481942}.
Mouse PG classificationNA
click here to return to the previous page