Gene Information | |
---|---|
Gene Name | B2AR |
Organism | Homo sapiens (Human) |
Gene Length | 413 |
Protein Names | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) |
Target Name | NA |
Target Type | NA |
Gene Age | NA |
Evolutionary Stage | NA |
AlphaFoldDB | P07550 |
Gene Card | ADRB2 |
Uniprot ID | P07550 |
Pfam | PF00001 |
In ASD | yes |
Allosteric Prediction | NA |
Ortholog in Animals | NA |
Ohnologs | NA |
Paralogs | NA |
Tissue | NA |
Tissue Specificity | NA |
Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002865(Rat);0.011765(Rabbit) |
Gene Ontology (biological process) |
|
Gene Ontology (cellular component) |
|
Gene Ontology (molecular function) |
|
PDB | 1GQ4 (X-ray 1.90A ) 2R4R (X-ray 3.40A ) 2R4S (X-ray 3.40A ) 2RH1 (X-ray 2.40A ) 3D4S (X-ray 2.80A ) 3KJ6 (X-ray 3.40A ) 3NY8 (X-ray 2.84A ) 3NY9 (X-ray 2.84A ) 3NYA (X-ray 3.16A ) 3P0G (X-ray 3.50A ) 3PDS (X-ray 3.50A ) 3SN6 (X-ray 3.20A ) 4GBR (X-ray 3.99A ) 4LDE (X-ray 2.79A ) 4LDL (X-ray 3.10A ) 4LDO (X-ray 3.20A ) 4QKX (X-ray 3.30A ) 5D5A (X-ray 2.48A ) 5D5B (X-ray 3.80A ) 5D6L (X-ray 3.20A ) 5JQH (X-ray 3.20A ) 5X7D (X-ray 2.70A ) 6E67 (X-ray 3.70A ) 6KR8 (NMR - ) 6MXT (X-ray 2.96A ) 6N48 (X-ray 3.20A ) 6NI3 (EM 3.80A ) 6OBA (X-ray 3.10A ) 6PRZ (X-ray 2.80A ) 6PS0 (X-ray 3.40A ) 6PS1 (X-ray 3.20A ) 6PS2 (X-ray 2.40A ) 6PS3 (X-ray 2.50A ) 6PS4 (X-ray 2.60A ) 6PS5 (X-ray 2.90A ) 6PS6 (X-ray 2.70A ) 7BZ2 (EM 3.82A ) 7DHI (EM 3.26A ) 7DHR (EM 3.80A ) |
DBSNP | rs33973603 rs1042713 rs1042714 rs990810566 rs1800888 rs3729943 rs771585355 |
Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23166351, ECO:0000269|PubMed:25220262, ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}; Multi-pass membrane protein {ECO:0000269|PubMed:19584355}. Early endosome {ECO:0000269|PubMed:20559325}. Golgi apparatus {ECO:0000269|PubMed:27481942}. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). {ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:27481942}. |
Mouse PG classification | NA |
click here to return to the previous page |