| Gene Information | |
|---|---|
| Gene Name | B0AT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 634 |
| Protein Names | Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q695T7 |
| Gene Card | SLC6A19 |
| Uniprot ID | Q695T7 |
| Pfam | PF00209 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Robust expression in kidney and small intestine, with minimal expression in pancreas (PubMed:18424768, PubMed:15286787). Also expressed in stomach, liver, duodenum, ileocecum, colon and prostate. Not detected in testis, whole brain, cerebellum, fetal liver, spleen, skeletal muscle, uterus, heart or lung. {ECO:0000269|PubMed:15286787, ECO:0000269|PubMed:15286788, ECO:0000269|PubMed:18424768}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6M17 (EM 2.90A ) 6M18 (EM 2.90A ) 6M1D (EM 4.50A ) 7DWX (EM 8.30A ) 7V61 (EM 3.20A ) |
| DBSNP | rs762989809 rs1251095994 rs757679627 rs121434346 rs758492838 rs200745023 rs7732589 rs148139045 rs200842846 rs142164435 rs765501634 rs1236852017 rs745524993 rs751554174 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:26240152}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:18424768}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with ACE2 on the apical membrane of cells lining villi of the jejunum, ileum and on kidney proximal tubules. {ECO:0000269|PubMed:18424768}. |
| Mouse PG classification | NA |
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