| Gene Information | |
|---|---|
| Gene Name | AXIN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 862 |
| Protein Names | Axin-1 (Axis inhibition protein 1) (hAxin) |
| Target Name | axin-1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000103126 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O15169 |
| Gene Card | AXIN1 |
| Uniprot ID | O15169 |
| Pfam | PF16646; PF08833; PF00778; PF00615 |
| In ASD | no |
| Allosteric Prediction | yes (0.158752626) |
| Ortholog in Animals | Alpaca_ AXIN1 ( ortholog_one2one ) Dog_ AXIN1 ( ortholog_one2one ) GuineaPig_ AXIN1 ( ortholog_one2one ) Macaque_ AXIN1 ( ortholog_one2one ) Mouse_ Axin1 ( ortholog_one2one ) Pig_ AXIN1 ( ortholog_one2one ) Rat_ Axin1 ( ortholog_one2one ) |
| Ohnologs | AXIN2 |
| Paralogs | RGS18, RGS5, RGS3, RGS20, RGS2, RGSL1, RGS12, RGS21, RGS1, RGS11, RGS17, RGS7, RGS14, AXIN2, RGS22, RGS4, RGS6, RGS9, RGS13, RGS19, RGS8, RGS16, RGS10 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. |
| Pharmacological Animal Models | 0.188299(Chimpanzee);0.023983(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1DK8 (X-ray 1.57A ) 1EMU (X-ray 1.90A ) 1O9U (X-ray 2.40A ) 3ZDI (X-ray 2.64A ) 4B7T (X-ray 2.77A ) 4NM0 (X-ray 2.50A ) 4NM3 (X-ray 2.10A ) 4NM5 (X-ray 2.30A ) 4NM7 (X-ray 2.30A ) 4NU1 (X-ray 2.50A ) 5WZZ (X-ray 2.10A ) 6JCK (X-ray 3.09A ) |
| DBSNP | rs779951904 rs116350678 rs117208012 rs34015754 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16601693}. Nucleus {ECO:0000269|PubMed:17210684}. Membrane {ECO:0000250|UniProtKB:O35625}. Cell membrane {ECO:0000250|UniProtKB:O35625}. Note=MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX (PubMed:17210684). {ECO:0000250|UniProtKB:O35625, ECO:0000269|PubMed:17210684}. |
| Mouse PG classification | NA |
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