| Gene Information | |
|---|---|
| Gene Name | AVIL |
| Organism | Homo sapiens (Human) |
| Gene Length | 819 |
| Protein Names | Advillin (p92) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000135407 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75366 |
| Gene Card | AVIL |
| Uniprot ID | O75366 |
| Pfam | PF00626; PF02209 |
| In ASD | no |
| Allosteric Prediction | no (-1.088059762) |
| Ortholog in Animals | Alpaca_ AVIL ( ortholog_one2one ) Dog_ AVIL ( ortholog_one2one ) GuineaPig_ AVIL ( ortholog_one2one ) Macaque_ AVIL ( ortholog_one2one ) Mouse_ Avil ( ortholog_one2one ) Pig_ AVIL ( ortholog_one2one ) Rat_ Avil ( ortholog_one2one ) Rabbit_ AVIL ( ortholog_one2one ) |
| Ohnologs | SCIN, VIL1, VILL |
| Paralogs | VIL1, VILL, SCIN, SVIL, CAPG, FLII, GSN |
| Tissue | NA |
| Tissue Specificity | Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus (PubMed:12034507). Expressed in podocytes (at protein level) (PubMed:29058690). {ECO:0000269|PubMed:12034507, ECO:0000269|PubMed:29058690}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1UND (NMR - ) |
| DBSNP | rs138047529 rs2172521 rs763782471 rs1334894971 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:29058690}. Cell projection, lamellipodium {ECO:0000269|PubMed:29058690}. Cell junction, focal adhesion {ECO:0000269|PubMed:29058690}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9WU06}. Cell projection, axon {ECO:0000250|UniProtKB:Q9WU06}. Note=In podocytes, present in the F-actin-enriched cell periphery that generates lamellipodia and focal adhesions. {ECO:0000269|PubMed:29058690}. |
| Mouse PG classification | NA |
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