| Gene Information | |
|---|---|
| Gene Name | AUTS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1259 |
| Protein Names | Autism susceptibility gene 2 protein |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000158321 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8WXX7 |
| Gene Card | AUTS2 |
| Uniprot ID | Q8WXX7 |
| Pfam | PF15336 |
| In ASD | no |
| Allosteric Prediction | no (-0.7753941) |
| Ortholog in Animals | Alpaca_ AUTS2 ( ortholog_one2one ) Dog_ AUTS2 ( ortholog_one2one ) GuineaPig_ AUTS2 ( ortholog_one2one ) Macaque_ AUTS2 ( ortholog_one2one ) Mouse_ Auts2 ( ortholog_one2one ) Pig_ AUTS2 ( ortholog_one2one ) Rat_ Auts2l1 ( ortholog_one2one ) Rabbit_ AUTS2 ( ortholog_one2one ) |
| Ohnologs | FBRSL1 |
| Paralogs | FBRS, FBRSL1 |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in brain, skeletal muscle and kidney. Also expressed in placenta, lung and leukocytes. {ECO:0000269|PubMed:12160723, ECO:0000269|PubMed:23332918}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2293507 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:25519132}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0A087WPF7}. Cell projection, growth cone {ECO:0000250|UniProtKB:A0A087WPF7}. Note=Detected both in cytoplasm and nucleus. Colocalizes with RAC1 at actin-rich growth cones. Detected on the promoter region of actively transcribed genes. {ECO:0000250|UniProtKB:A0A087WPF7}. |
| Mouse PG classification | NA |
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