| Gene Information | |
|---|---|
| Gene Name | AURKC |
| Organism | Homo sapiens (Human) |
| Gene Length | 309 |
| Protein Names | Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C) |
| Target Name | aurora kinase c |
| Target Type | Clinical trial target |
| Gene Age | 132 ( ENSG00000105146 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UQB9 |
| Gene Card | AURKC |
| Uniprot ID | Q9UQB9 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.17592255) |
| Ortholog in Animals | Alpaca_ AURKC ( ortholog_one2one ) Dog_ AURKC ( ortholog_one2one ) GuineaPig_ AURKC ( ortholog_one2one ) Mouse_ Aurkc ( ortholog_one2one ) Rat_ Aurkc ( ortholog_one2one ) Rabbit_ AURKC ( ortholog_one2one ) |
| Ohnologs | AURKA, AURKB |
| Paralogs | AURKA, AURKB |
| Tissue | testis |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase. {ECO:0000269|PubMed:15670791}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6GR8 (X-ray 1.75A ) 6GR9 (X-ray 2.25A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus. Chromosome. Chromosome, centromere {ECO:0000269|PubMed:27332895}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15938719}. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. {ECO:0000269|PubMed:21531210}. |
| Mouse PG classification | NA |
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