Gene Information
Gene NameAURKB
OrganismHomo sapiens (Human)
Gene Length344
Protein NamesAurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
Target Nameaurora b messenger rna
Target TypeClinical trial target
Gene Age544 ( ENSG00000178999 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ96GD4
Gene CardAURKB
Uniprot IDQ96GD4
PfamPF00069
In ASDyes
Allosteric Predictionyes (1.000001947)
Ortholog in AnimalsAlpaca_ AURKB ( ortholog_one2one )
Alpaca_ AURKB ( ortholog_one2many )
Dog_ AURKB ( ortholog_one2many )
GuineaPig_ AURKB ( ortholog_one2one )
Macaque_ AURKB ( ortholog_one2one )
Mouse_ Aurkb ( ortholog_one2one )
Pig_ AURKB ( ortholog_one2one )
Rat_ Aurkb ( ortholog_one2one )
Rabbit_ AURKB ( ortholog_one2one )
OhnologsAURKA, AURKC
ParalogsAURKC, AURKA
Tissueappendix, colon, dura.mater, heart, tongue
Tissue SpecificityHigh level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase. {ECO:0000269|PubMed:9809983, ECO:0000269|PubMed:9858806}.;
[Isoform 3]: Not expressed in normal liver, high expression in metastatic liver. {ECO:0000269|PubMed:19134008}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4AF3  (X-ray  2.75A  ) 
DBSNP rs55878091  rs3027254  rs55871613  rs1059476 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:20959462}. Chromosome {ECO:0000269|PubMed:20929775}. Chromosome, centromere {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:20929775}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:26829474}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:20605920}. Midbody {ECO:0000269|PubMed:16179162, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:23036704}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:20929775). Colocalized with gamma tubulin in the midbody (PubMed:17726514). Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC (PubMed:20605920). Colocalized with SIRT2 during cytokinesis with the midbody (PubMed:17726514). Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12 (PubMed:20929775). {ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:20605920, ECO:0000269|PubMed:20929775}.
Mouse PG classificationNA
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