| Gene Information | |
|---|---|
| Gene Name | CYTH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) |
| Target Name | cytohesin-2 |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000105443 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99418 |
| Gene Card | CYTH2 |
| Uniprot ID | Q99418 |
| Pfam | PF00169; PF01369 |
| In ASD | no |
| Allosteric Prediction | yes (0.608559923) |
| Ortholog in Animals | Alpaca_ CYTH2 ( ortholog_one2one ) Dog_ CYTH2 ( ortholog_one2one ) GuineaPig_ CYTH2 ( ortholog_one2one ) Macaque_ CYTH2 ( ortholog_one2one ) Mouse_ Cyth2 ( ortholog_one2one ) Pig_ CYTH2 ( ortholog_one2one ) Rat_ Cyth2 ( ortholog_one2one ) Rabbit_ CYTH2 ( ortholog_one2one ) |
| Ohnologs | CYTH4, CYTH3, CYTH1 |
| Paralogs | PSD2, PSD3, ARFGEF2, CYTH4, MON2, GBF1, ARFGEF1, PSD, PSD4, FBXO8, CYTH1, IQSEC3, IQSEC1, IQSEC2, CYTH3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000305|PubMed:9417041}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1PBV (X-ray 2.00A ) 1R8M (X-ray 1.70A ) 1R8Q (X-ray 1.86A ) 1R8S (X-ray 1.46A ) 1S9D (X-ray 1.80A ) 4JMI (X-ray 1.50A ) 4JMO (X-ray 1.80A ) 4JWL (X-ray 1.95A ) 4JXH (X-ray 1.47A ) 4L5M (X-ray 1.80A ) 4Z21 (X-ray 2.05A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17398095}; Peripheral membrane protein {ECO:0000269|PubMed:17398095}. Cytoplasm {ECO:0000269|PubMed:17398095}. Cell projection {ECO:0000250|UniProtKB:P63034}. Cell projection, growth cone {ECO:0000250|UniProtKB:P63034}. Cell junction, tight junction {ECO:0000250|UniProtKB:P63034}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P63034}. Note=Both isoform 1 and isoform 2 are recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to plasma membrane (PubMed:17398095). In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas. {ECO:0000250|UniProtKB:P63034, ECO:0000269|PubMed:17398095}. |
| Mouse PG classification | NA |
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