| Gene Information | |
|---|---|
| Gene Name | ARL6IP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 203 |
| Protein Names | ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Apoptotic regulator in the membrane of the endoplasmic reticulum) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000170540 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15041 |
| Gene Card | ARL6IP1 |
| Uniprot ID | Q15041 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.786343858) |
| Ortholog in Animals | Alpaca_ ARL6IP1 ( ortholog_one2one ) GuineaPig_ ARL6IP1 ( ortholog_one2one ) Mouse_ Arl6ip1 ( ortholog_one2one ) Rat_ Arl6ip1 ( ortholog_one2one ) Rabbit_ ARL6IP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all hematopoietic cell lineages, but the highest level of expression is found in early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney and spleen. Not detected in heart. {ECO:0000269|PubMed:10995579}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endomembrane system {ECO:0000269|PubMed:10995579}; Multi-pass membrane protein {ECO:0000269|PubMed:10995579}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12754298, ECO:0000269|PubMed:24076029, ECO:0000269|PubMed:24262037}; Multi-pass membrane protein {ECO:0000269|PubMed:24076029}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9JKW0}. Note=Predominantly localized to intracytoplasmic membranes. Preferentially localizes at the ER tubules and the edge of the ER sheets, both of which are characterized by a high membrane curvature. {ECO:0000269|PubMed:24262037}. |
| Mouse PG classification | NA |
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