| Gene Information | |
|---|---|
| Gene Name | MCT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 478 |
| Protein Names | Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O60669 |
| Gene Card | SLC16A7 |
| Uniprot ID | O60669 |
| Pfam | PF07690 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in heart and in blood lymphocytes and monocytes (at protein level) (PubMed:15505343). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and leukocyte (PubMed:9786900). Restricted expression in normal tissues, but widely expressed in cancer cells. {ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:9786900}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7BP3 (EM 3.80A ) |
| DBSNP | rs3763980 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:32415067}; Multi-pass membrane protein {ECO:0000269|PubMed:32415067}. Basolateral cell membrane {ECO:0000250|UniProtKB:P53988}; Multi-pass membrane protein {ECO:0000269|PubMed:32415067}. Cytoplasm {ECO:0000250|UniProtKB:O70451}. Note=Requires the ancillary protein, EMB for plasma membrane localization (By similarity). Colocalizes with BSG in spermatozoa. Detected in the cytoplasm of Sertoli cells (By similarity). {ECO:0000250|UniProtKB:O70451, ECO:0000250|UniProtKB:Q63344}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |