| Gene Information | |
|---|---|
| Gene Name | ATRN |
| Organism | Homo sapiens (Human) |
| Gene Length | 1429 |
| Protein Names | Attractin (DPPT-L) (Mahogany homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000088812 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75882 |
| Gene Card | ATRN |
| Uniprot ID | O75882 |
| Pfam | PF00431; PF01344; PF00059; PF01437 |
| In ASD | no |
| Allosteric Prediction | no (-0.914865456) |
| Ortholog in Animals | Alpaca_ ATRN ( ortholog_one2one ) Dog_ ATRN ( ortholog_one2one ) GuineaPig_ ATRN ( ortholog_one2one ) Macaque_ ATRN ( ortholog_one2one ) Mouse_ Atrn ( ortholog_one2one ) Pig_ ATRN ( ortholog_one2one ) Rat_ Atrn ( ortholog_one2one ) Rabbit_ ATRN ( ortholog_one2one ) |
| Ohnologs | ATRNL1 |
| Paralogs | LAMB2, LAMC3, NTN4, LAMB1, LAMA3, LAMC1, ATRNL1, LAMA2, TMEFF2, NTN1, NTN3, LAMC2, TMEFF1, LAMA1, AGRN, LAMB4, NTNG2, NTNG1, LAMA4, MEGF9, MEGF8, LAMB3, EGFLAM, LAMA5, NTN5, USH2A, HSPG2 |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes. {ECO:0000269|PubMed:10811918, ECO:0000269|PubMed:17261078}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs6107308 rs17782078 rs3886999 rs12329487 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:7539799}; Single-pass type I membrane protein {ECO:0000269|PubMed:7539799}.; [Isoform 2]: Secreted {ECO:0000269|PubMed:7539799, ECO:0000269|PubMed:9736737}.; [Isoform 3]: Secreted {ECO:0000269|PubMed:7539799}. |
| Mouse PG classification | NA |
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