| Gene Information | |
|---|---|
| Gene Name | ATR |
| Organism | Homo sapiens (Human) |
| Gene Length | 2644 |
| Protein Names | Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) |
| Target Name | serine/threonine-protein kinase atr |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000175054 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13535 |
| Gene Card | ATR |
| Uniprot ID | Q13535 |
| Pfam | PF02259; PF02260; PF00454; PF08064 |
| In ASD | no |
| Allosteric Prediction | yes (0.461949045) |
| Ortholog in Animals | Alpaca_ ATR ( ortholog_one2one ) Dog_ ATR ( ortholog_one2one ) GuineaPig_ ATR ( ortholog_one2one ) Macaque_ ATR ( ortholog_one2one ) Mouse_ Atr ( ortholog_one2one ) Pig_ ATR ( ortholog_one2one ) Rat_ Atr ( ortholog_one2one ) Rabbit_ ATR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRRAP, ATM, SMG1, PRKDC, MTOR |
| Tissue | NA |
| Tissue Specificity | Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary. {ECO:0000269|PubMed:11470508, ECO:0000269|PubMed:8610130, ECO:0000269|PubMed:8843195}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.024913(Rat);0.100806(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5YZ0 (EM 4.70A ) |
| DBSNP | rs35306038 rs28897763 rs2227928 rs2229033 rs28897764 rs28910271 rs34253059 rs34766606 rs34124242 rs55724025 rs55894265 rs35134774 rs28910273 rs387906797 rs2229032 rs33972295 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14871897, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:8843195}. Chromosome {ECO:0000250|UniProtKB:Q9JKK8}. Note=Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling. |
| Mouse PG classification | NA |
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