| Gene Information | |
|---|---|
| Gene Name | ATR |
| Organism | Homo sapiens (Human) |
| Gene Length | 564 |
| Protein Names | Anthrax toxin receptor 1 (Tumor endothelial marker 8) |
| Target Name | serine/threonine-protein kinase atr |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000175054 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H6X2 |
| Gene Card | ANTXR1 |
| Uniprot ID | Q9H6X2 |
| Pfam | PF05586; PF05587; PF00092 |
| In ASD | no |
| Allosteric Prediction | yes (0.461949045) |
| Ortholog in Animals | Alpaca_ ATR ( ortholog_one2one ) Dog_ ATR ( ortholog_one2one ) GuineaPig_ ATR ( ortholog_one2one ) Macaque_ ATR ( ortholog_one2one ) Mouse_ Atr ( ortholog_one2one ) Pig_ ATR ( ortholog_one2one ) Rat_ Atr ( ortholog_one2one ) Rabbit_ ATR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRRAP, ATM, SMG1, PRKDC, MTOR |
| Tissue | NA |
| Tissue Specificity | Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells. {ECO:0000269|PubMed:15777794}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3N2N (X-ray 1.80A ) 6ADL (EM 3.08A ) 6ADM (EM 2.84A ) 6ADR (EM 3.38A ) 6CX1 (EM 3.80A ) |
| DBSNP | rs28365986 rs119475040 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, filopodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia (PubMed:16762926). Colocalizes with actin at the base of lamellipodia (PubMed:16762926). {ECO:0000269|PubMed:16762926}. |
| Mouse PG classification | NA |
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