| Gene Information | |
|---|---|
| Gene Name | ATR |
| Organism | Homo sapiens (Human) |
| Gene Length | 421 |
| Protein Names | Alpha-1-antitrypsin-related protein (Protease inhibitor 1-like) (Serpin A2) |
| Target Name | serine/threonine-protein kinase atr |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000175054 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P20848 |
| Gene Card | SERPINA2 |
| Uniprot ID | P20848 |
| Pfam | PF00079 |
| In ASD | no |
| Allosteric Prediction | yes (0.461949045) |
| Ortholog in Animals | Alpaca_ ATR ( ortholog_one2one ) Dog_ ATR ( ortholog_one2one ) GuineaPig_ ATR ( ortholog_one2one ) Macaque_ ATR ( ortholog_one2one ) Mouse_ Atr ( ortholog_one2one ) Pig_ ATR ( ortholog_one2one ) Rat_ Atr ( ortholog_one2one ) Rabbit_ ATR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRRAP, ATM, SMG1, PRKDC, MTOR |
| Tissue | NA |
| Tissue Specificity | Expressed in the liver, leukocytes and testis. Also detected in brain, colon, uterus, esophagus, spleen, trachea, kidney and lung. {ECO:0000269|PubMed:17135331, ECO:0000269|PubMed:23826168}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000269|PubMed:23826168}. |
| Mouse PG classification | NA |
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