Gene Information
Gene NameATPIG
OrganismHomo sapiens (Human)
Gene Length1132
Protein NamesPhospholipid-transporting ATPase IG (EC 7.6.2.1) (ATPase IQ) (ATPase class VI type 11C) (P4-ATPase flippase complex alpha subunit ATP11C)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ8NB49
Gene CardATP11C
Uniprot IDQ8NB49
PfamPF16212; PF16209
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:15533723, ECO:0000269|PubMed:26567335}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6LKN  (X-ray  3.90A  7BSP  (EM  4.00A  7BSQ  (EM  3.20A  7BSS  (EM  3.30A  7BSU  (EM  3.20A  7BSV  (EM  3.00A  7BSW  (EM  3.90A  7VSG  (EM  3.90A  7VSH  (EM  3.40A 
DBSNP rs2491014  rs1556323334  rs17281983  rs55724992 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25315773};
Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25315773};
Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:29123098};
Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:29123098};
Multi-pass membrane protein {ECO:0000255}. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Internalized via clathrin-dependent endocytosis in response to ca(2+) signaling induced by G-protein coupled serotonin and histamine receptors. {ECO:0000269|PubMed:29123098}.
Mouse PG classificationNA
click here to return to the previous page