| Gene Information | |
|---|---|
| Gene Name | ATAD3A |
| Organism | Homo sapiens (Human) |
| Gene Length | 634 |
| Protein Names | ATPase family AAA domain-containing protein 3A |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000197785 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NVI7 |
| Gene Card | ATAD3A |
| Uniprot ID | Q9NVI7 |
| Pfam | PF00004; PF12037 |
| In ASD | no |
| Allosteric Prediction | no (-0.683792346) |
| Ortholog in Animals | Dog_ ATAD3A ( ortholog_one2one ) GuineaPig_ ATAD3A ( ortholog_one2one ) Mouse_ Atad3a ( ortholog_one2one ) Pig_ ATAD3A ( ortholog_one2one ) Rat_ Atad3a ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ATAD3B, ATAD3C |
| Tissue | NA |
| Tissue Specificity | Overexpressed in lung adenocarcinomas (at protein level). {ECO:0000269|PubMed:20332122}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2274435 rs1570319915 rs1619896 rs760826883 rs1570345942 rs1057517687 rs1057517686 |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:20332122, ECO:0000269|PubMed:20349121}; Single-pass membrane protein {ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:20349121}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:17210950, ECO:0000269|PubMed:18063578}. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane (PubMed:20349121, PubMed:20154147). The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids (PubMed:18063578). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:20349121}. |
| Mouse PG classification | NA |
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