| Gene Information | |
|---|---|
| Gene Name | ATP8B4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1192 |
| Protein Names | Probable phospholipid-transporting ATPase IM (EC 7.6.2.1) (ATPase class I type 8B member 4) (P4-ATPase flippase complex alpha subunit ATP8B4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000104043 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TF62 |
| Gene Card | ATP8B4 |
| Uniprot ID | Q8TF62 |
| Pfam | PF16212; PF16209 |
| In ASD | no |
| Allosteric Prediction | no (-0.762301108) |
| Ortholog in Animals | Alpaca_ ATP8B4 ( ortholog_one2one ) Dog_ ATP8B4 ( ortholog_one2one ) GuineaPig_ ATP8B4 ( ortholog_one2one ) Macaque_ ATP8B4 ( ortholog_one2one ) Mouse_ Atp8b4 ( ortholog_one2one ) Pig_ ATP8B4 ( ortholog_one2one ) Rat_ Atp8b4 ( ortholog_one2one ) Rabbit_ ATP8B4 ( ortholog_one2one ) |
| Ohnologs | ATP8B1, ATP8B3, ATP8B2 |
| Paralogs | ATP10D, ATP11A, ATP8A2, ATP11C, ATP10A, ATP11B, ATP8B1, ATP9A, ATP10B, ATP8B2, ATP8A1, ATP9B, ATP8B3 |
| Tissue | bone.marrow |
| Tissue Specificity | Ubiquitously expressed at moderate levels. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16963151 rs2452524 rs16962989 rs16962987 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20947505}; Multi-pass membrane protein {ECO:0000269|PubMed:20947505}. Golgi apparatus {ECO:0000269|PubMed:20947505}. |
| Mouse PG classification | NA |
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