| Gene Information | |
|---|---|
| Gene Name | ATP8B3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1300 |
| Protein Names | Phospholipid-transporting ATPase IK (EC 7.6.2.1) (ATPase class I type 8B member 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000130270 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60423 |
| Gene Card | ATP8B3 |
| Uniprot ID | O60423 |
| Pfam | PF16212; PF16209 |
| In ASD | no |
| Allosteric Prediction | no (-1.015150149) |
| Ortholog in Animals | Alpaca_ ATP8B3 ( ortholog_one2one ) Macaque_ ATP8B3 ( ortholog_one2one ) Mouse_ Atp8b3 ( ortholog_one2one ) Pig_ ATP8B3 ( ortholog_one2one ) Rat_ Atp8b3 ( ortholog_one2one ) |
| Ohnologs | ATP8B1, ATP8B4, ATP8B2 |
| Paralogs | ATP8B4, ATP10D, ATP11A, ATP8A2, ATP11C, ATP10A, ATP11B, ATP8B1, ATP9A, ATP10B, ATP8B2, ATP8A1, ATP9B |
| Tissue | testis |
| Tissue Specificity | Isoform 3 was only detected in testis. {ECO:0000269|PubMed:12880872}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7250872 rs8100856 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q6UQ17}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20947505}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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