Gene Information
Gene NameATP7B
OrganismHomo sapiens (Human)
Gene Length1465
Protein NamesCopper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa]
Target NameNA
Target TypeNA
Gene Age>4290 ( ENSG00000123191 )
Evolutionary StageCellular_organisms
AlphaFoldDBP35670
Gene CardATP7B
Uniprot IDP35670
PfamPF00403
In ASDno
Allosteric Predictionno (-0.214199262)
Ortholog in AnimalsAlpaca_ ATP7B ( ortholog_one2one )
Dog_ ATP7B ( ortholog_one2one )
GuineaPig_ ATP7B ( ortholog_one2one )
Macaque_ ATP7B ( ortholog_one2one )
Mouse_ Atp7b ( ortholog_one2one )
Pig_ ATP7B ( ortholog_one2one )
Rat_ Atp7b ( ortholog_one2one )
Rabbit_ ATP7B ( ortholog_one2one )
OhnologsATP7A
ParalogsATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP2B2, ATP13A4, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP2C1, ATP13A1
Tissuetestis
Tissue SpecificityMost abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues.
Pharmacological Animal Models0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2ARF  (NMR  -  )  2EW9  (NMR  -  )  2KOY  (NMR  -  )  2LQB  (NMR  -  )  2N7Y  (NMR  -  )  2ROP  (NMR  -  )  6A71  (X-ray  1.60A  )  6A72  (X-ray  2.10A  ) 
DBSNP rs587783319  rs201738967  rs1566605396  rs786204643  rs1429553821  rs1566603189  rs557577836  rs373762572  rs551275663  rs774102085  rs770903362  rs1801243  rs587783298  rs1801244  rs1282624946  rs1566580253  rs138427376  rs572122562  rs187046823  rs778475094  rs797045402  rs1566559224  rs760501309  rs1173050016  rs376565432  rs752850609  rs374172791  rs587783299  rs200728096  rs186924074  rs72552285  rs121907998  rs372436901  rs72552259  rs1555291809  rs121908001  rs1212479289  rs767218895  rs121908000  rs1555291285  rs137853285  rs1394999756  rs1394999756  rs756883878  rs765667658  rs773447981  rs770533110  rs1593726081  rs1362773192  rs766907687  rs1555291147  rs28942075  rs28942075  rs121907997  rs121907997  rs772595172  rs193922103  rs1217463955  rs137853284  rs28942074  rs28942074  rs137853284  rs751798708  rs541408630  rs751710854  rs368589213  rs539585071  rs1061472  rs773809011  rs768671894  rs1057520235  rs191312027  rs376355660  rs121907994  rs587783304  rs786204718  rs483352684  rs540935874  rs121907993  rs121907993  rs1230241288  rs1052485948  rs534960245  rs1555288410  rs750019452  rs367855110  rs1057517310  rs28942076  rs779323689  rs28942076  rs1169959260  rs732774  rs60003608  rs121907996  rs774028495  rs770340441  rs201061621  rs778163447  rs72552255  rs1038582488  rs750407121  rs1487547257  rs199623434  rs41292782  rs201038679  rs201038679  rs777791532  rs770782111  rs751078884  rs201497300  rs775055397  rs587783307  rs1414727042  rs747584649  rs747584649  rs772089544  rs755851188  rs371840514  rs776490710  rs1416453532  rs1555286628  rs1555286620  rs753594031  rs761147984  rs59959366  rs746485916  rs1412025509  rs778543794  rs764131178  rs587783309  rs374094065  rs376910645  rs1555286478  rs76151636  rs1423701688  rs1206016866  rs1286080173  rs1555285911  rs778825095  rs1397083296  rs1555285891  rs761632029  rs786204483  rs560952220  rs764041557  rs775541743  rs541208827  rs759109027  rs182659444  rs1801249  rs778749563  rs587783313  rs1213481140  rs60431989  rs1566462533  rs755554442  rs377297166  rs1330620114  rs867107727  rs777879359  rs1555285311  rs749085322  rs756029120  rs1318758433  rs137853279  rs1387431334  rs587783315  rs786204547  rs7334118  rs1555284582  rs776280797  rs193922107  rs1486594906  rs200911496  rs568009639  rs374628199  rs1277243795  rs587783316  rs372042739  rs1555283946  rs769484789  rs1566444586  rs121907992  rs1555283916  rs1314712150  rs121907990  rs758355520  rs778914828  rs755202606  rs762866453  rs373748155  rs776300396  rs1340942427  rs199821556  rs148399850  rs753044473  rs377144951  rs749380700  rs753330854  rs1333619338  rs1131691741  rs779494870  rs587783317  rs587783317  rs587783318  rs1388795855  rs1160679283  rs1555282751  rs759551693  rs776848753  rs749171049  rs1555282678  rs780811477  rs780811477  rs1365425480  rs181250704  rs587783320  rs375692175  rs60986317 
Subcellular location [CC]Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:17919502, ECO:0000269|PubMed:19033537, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876};
Multi-pass membrane protein {ECO:0000255}. Late endosome {ECO:0000269|PubMed:11231950, ECO:0000269|PubMed:15681833}. Note=Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420). {ECO:0000269|PubMed:10942420, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:9307043}.;
[Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:9307043};
Multi-pass membrane protein {ECO:0000269|PubMed:9307043}.;
[Isoform 2]: Cytoplasm {ECO:0000269|PubMed:9307043}.;
[WND/140 kDa]: Mitochondrion {ECO:0000269|PubMed:9600907}.
Mouse PG classificationNA
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