| Gene Information | |
|---|---|
| Gene Name | ATP6V1B2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 511 |
| Protein Names | V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2) |
| Target Name | v-atpase subunits |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000147416 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P21281 |
| Gene Card | ATP6V1B2 |
| Uniprot ID | P21281 |
| Pfam | PF00006; PF02874 |
| In ASD | no |
| Allosteric Prediction | yes (0.849208781) |
| Ortholog in Animals | Alpaca_ ATP6V1B2 ( ortholog_one2one ) Dog_ ATP6V1B2 ( ortholog_one2one ) GuineaPig_ ATP6V1B2 ( ortholog_one2one ) Macaque_ ATP6V1B2 ( ortholog_one2one ) Mouse_ Atp6v1b2 ( ortholog_one2one ) Pig_ ATP6V1B2 ( ortholog_one2one ) Rat_ Atp6v1b2 ( ortholog_one2one ) Rabbit_ ATP6V1B2 ( ortholog_one2one ) |
| Ohnologs | ATP6V1B1 |
| Paralogs | ATP5F1B, ATP6V1A, ATP5F1A, ATP6V1B1 |
| Tissue | NA |
| Tissue Specificity | Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level). {ECO:0000269|PubMed:29993276}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.048976(Rat);0.304789(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 6WLZ (EM 2.90A ) 6WM2 (EM 3.10A ) 6WM3 (EM 3.40A ) 6WM4 (EM 3.60A ) 7U4T (EM 3.60A ) 7UNF (EM 4.08A ) |
| DBSNP | rs730882177 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:29993276}. Melanosome {ECO:0000269|PubMed:12643545}. Cytoplasm {ECO:0000250|UniProtKB:P62814}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P62815}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P62815}; Peripheral membrane protein {ECO:0000305}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545}. |
| Mouse PG classification | LPG |
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