| Gene Information | |
|---|---|
| Gene Name | ATP6V1B1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 513 |
| Protein Names | V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1) |
| Target Name | v-atpase subunits |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000116039 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P15313 |
| Gene Card | ATP6V1B1 |
| Uniprot ID | P15313 |
| Pfam | PF00006; PF02874 |
| In ASD | no |
| Allosteric Prediction | yes (0.064150559) |
| Ortholog in Animals | Alpaca_ ATP6V1B1 ( ortholog_one2one ) Dog_ ATP6V1B1 ( ortholog_one2one ) GuineaPig_ ATP6V1B1 ( ortholog_one2one ) Macaque_ ATP6V1B1 ( ortholog_one2one ) Mouse_ Atp6v1b1 ( ortholog_one2one ) Pig_ ATP6V1B1 ( ortholog_one2one ) Rat_ Atp6v1b1 ( ortholog_one2one ) Rabbit_ ATP6V1B1 ( ortholog_one2one ) |
| Ohnologs | ATP6V1B2 |
| Paralogs | ATP5F1B, ATP6V1A, ATP5F1A, ATP6V1B2 |
| Tissue | kidney, salivary.gland, parotid.gland, placenta, submandibular.gland, zone.of.skin, cortex.of.kidney, lower.leg.skin, minor.salivary.gland |
| Tissue Specificity | Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level) (PubMed:29993276, PubMed:16769747). Expressed in the cochlea and endolymphatic sac (PubMed:9916796). {ECO:0000269|PubMed:16769747, ECO:0000269|PubMed:29993276, ECO:0000269|PubMed:9916796}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.007735(Rat);0.308122(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17720303 rs121964879 rs121964880 rs1343871627 rs727505222 rs782500780 rs114234874 rs1161604514 rs1553420413 rs781838938 rs142905621 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:16769747, ECO:0000269|PubMed:29993276}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q91YH6}. |
| Mouse PG classification | NA |
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