Gene Information
Gene NameATP6V1A
OrganismHomo sapiens (Human)
Gene Length617
Protein NamesV-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)
Target Namev-type proton atpase catalytic subunit a
Target TypeNA
Gene Age>4290 ( ENSG00000114573 )
Evolutionary StageCellular_organisms
AlphaFoldDBP38606
Gene CardATP6V1A
Uniprot IDP38606
PfamPF00006; PF02874; PF16886
In ASDno
Allosteric Predictionyes (0.767089508)
Ortholog in AnimalsAlpaca_ ATP6V1A ( ortholog_one2one )
Dog_ ATP6V1A ( ortholog_one2one )
GuineaPig_ ATP6V1A ( ortholog_one2one )
Mouse_ Atp6v1a ( ortholog_one2one )
Pig_ ATP6V1A ( ortholog_one2one )
Rat_ Atp6v1a ( ortholog_one2one )
Rabbit_ ATP6V1A ( ortholog_one2one )
OhnologsNA
ParalogsATP5F1B, ATP5F1A, ATP6V1B1, ATP6V1B2
TissueNA
Tissue SpecificityHigh expression in the skin. {ECO:0000269|PubMed:28065471}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.047777(Rat);0.282963(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6WLZ  (EM  2.90A  )  6WM2  (EM  3.10A  )  6WM3  (EM  3.40A  )  6WM4  (EM  3.60A  )  7U4T  (EM  3.60A  )  7UNF  (EM  4.08A  ) 
DBSNP rs746407800  rs1553709380  rs1060505037  rs1553709855  rs1060505036  rs1553710664 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:29668857, ECO:0000269|PubMed:33208464}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P50516}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:23035048}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P31404};
Peripheral membrane protein {ECO:0000305}. Lysosome {ECO:0000250|UniProtKB:P50516}. Note=Co-localizes with WFS1 in the secretory granules in neuroblastoma cell lines. {ECO:0000269|PubMed:23035048}.
Mouse PG classificationNA
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