| Gene Information | |
|---|---|
| Gene Name | ENO3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 434 |
| Protein Names | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) |
| Target Name | beta-enolase |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000108515 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P13929 |
| Gene Card | ENO3 |
| Uniprot ID | P13929 |
| Pfam | PF00113; PF03952 |
| In ASD | no |
| Allosteric Prediction | yes (0.481248937) |
| Ortholog in Animals | Alpaca_ ENO3 ( ortholog_one2one ) Dog_ ENO3 ( ortholog_one2one ) GuineaPig_ ENO3 ( ortholog_one2one ) Macaque_ ENO3 ( ortholog_one2one ) Mouse_ Eno3 ( ortholog_one2one ) Pig_ ENO3 ( ortholog_one2one ) Rat_ Eno3 ( ortholog_one2one ) Rabbit_ ENO3 ( ortholog_one2one ) |
| Ohnologs | ENO1, ENO2 |
| Paralogs | ENO2, ENO1, ENO4 |
| Tissue | skeletal.muscle, artery, penis, tongue, heart |
| Tissue Specificity | The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.006897(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XSX (X-ray 1.70A ) |
| DBSNP | rs238238 rs238239 rs121918403 rs121918404 |
| Subcellular location [CC] | Cytoplasm. Note=Localized to the Z line. Some colocalization with CKM at M-band (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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