| Gene Information | |
|---|---|
| Gene Name | ATP6V0A4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 840 |
| Protein Names | V-type proton ATPase 116 kDa subunit a 4 (V-ATPase 116 kDa isoform a 4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform) |
| Target Name | v-atpase subunits |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000105929 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9HBG4 |
| Gene Card | ATP6V0A4 |
| Uniprot ID | Q9HBG4 |
| Pfam | PF01496 |
| In ASD | no |
| Allosteric Prediction | yes (0.227951876) |
| Ortholog in Animals | Alpaca_ ATP6V0A4 ( ortholog_one2one ) Alpaca_ ATP6V0A4 ( ortholog_one2many ) Dog_ ATP6V0A4 ( ortholog_one2one ) GuineaPig_ ATP6V0A4 ( ortholog_one2one ) Macaque_ ATP6V0A4 ( ortholog_one2one ) Mouse_ Atp6v0a4 ( ortholog_one2one ) Pig_ ATP6V0A4 ( ortholog_one2one ) Rat_ Atp6v0a4 ( ortholog_one2one ) Rabbit_ ATP6V0A4 ( ortholog_one2one ) |
| Ohnologs | ATP6V0A1, ATP6V0A2 |
| Paralogs | TCIRG1, ATP6V0A2, ATP6V0A1 |
| Tissue | kidney, salivary.gland, cortex.of.kidney |
| Tissue Specificity | Expressed in adult and fetal kidney. Found in the inner ear. {ECO:0000269|PubMed:12414817}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003059(Rat);0.333122(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 7UNF (EM 4.08A ) |
| DBSNP | rs10258719 rs1443883930 rs121908368 rs1026435 rs3807153 rs3807154 rs28939081 rs267606671 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:10973252}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q920R6}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron (PubMed:10973252). Localizes to the basolateral surface of beta-intercalated cells in the cortical collecting ducts of the distal nephron (By similarity). {ECO:0000250|UniProtKB:Q920R6, ECO:0000269|PubMed:10973252}. |
| Mouse PG classification | NA |
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