Gene Information

Gene Information
Gene Name	HLA-B
Organism	Homo sapiens (Human)
Gene Length	362
Protein Names	HLA class I histocompatibility antigen, B alpha chain (Human leukocyte antigen B) (HLA-B)
Target Name	hla class i histocompatibility antigen, b-57 alpha chain
Target Type	NA
Gene Age	3 ( ENSG00000206450 ) 3 ( ENSG00000223532 ) 3 ( ENSG00000224608 ) 3 ( ENSG00000228964 ) 3 ( ENSG00000232126 ) 382 ( ENSG00000234745 )
Evolutionary Stage	Vertebrata
AlphaFoldDB	P01889
Gene Card	HLA-B
Uniprot ID	P01889
Pfam	PF07654; PF00129; PF06623
In ASD	no
Allosteric Prediction	yes (0.480059076)
Ortholog in Animals	Alpaca_ PATR-H ( ortholog_one2one ) Mouse_ H2-M10.6 ( ortholog_many2many ) Mouse_ H2-M10.4 ( ortholog_many2many ) Mouse_ H2-M1 ( ortholog_many2many ) Mouse_ H2-D1 ( ortholog_many2many ) Mouse_ H2-Q1 ( ortholog_many2many ) Mouse_ H2-T3 ( ortholog_many2many ) Mouse_ H2-Q2 ( ortholog_many2many ) Mouse_ H2-Q4 ( ortholog_many2many ) Mouse_ Gm8909 ( ortholog_many2many ) Mouse_ H2-Q7 ( ortholog_many2many ) Mouse_ H2-M11 ( ortholog_many2many ) Mouse_ H2-Q10 ( ortholog_many2many ) Mouse_ H2-M10.1 ( ortholog_many2many ) Mouse_ Gm11127 ( ortholog_many2many ) Mouse_ H2-M9 ( ortholog_many2many ) Mouse_ H2-T23 ( ortholog_many2many ) Mouse_ H2-M5 ( ortholog_many2many ) Mouse_ H2-M3 ( ortholog_many2many ) Mouse_ H2-M10.3 ( ortholog_many2many ) Mouse_ H2-M10.2 ( ortholog_many2many ) Mouse_ H2-Q6 ( ortholog_many2many ) Mouse_ H2-T22 ( ortholog_many2many ) Mouse_ H2-M10.5 ( ortholog_many2many ) Mouse_ Gm7030 ( ortholog_many2many ) Mouse_ H2-T10 ( ortholog_many2many ) Mouse_ H2-M2 ( ortholog_many2many ) Mouse_ 2410137M14Rik ( ortholog_many2many ) Mouse_ H2-K1 ( ortholog_many2many ) Rat_ AABR07072807.1 ( ortholog_many2many ) Rat_ RT1-S2 ( ortholog_many2many ) Rat_ RT1-M1-4 ( ortholog_many2many ) Rat_ RT1-CE16 ( ortholog_many2many ) Rat_ RT1-S3 ( ortholog_many2many ) Rat_ AABR07044308.2 ( ortholog_many2many ) Rat_ RT1-M1-2 ( ortholog_many2many ) Rat_ AABR07044383.1 ( ortholog_many2many ) Rat_ AABR07044308.1 ( ortholog_many2many ) Rat_ RT1-M3-1 ( ortholog_many2many ) Rat_ RT1-CE14 ( ortholog_many2many ) Rat_ RT1-CE11 ( ortholog_many2many ) Rat_ RT1-N3 ( ortholog_many2many ) Rat_ RT1-CE2 ( ortholog_many2many ) Rat_ RT1-CE1 ( ortholog_many2many ) Rat_ AABR07044397.1 ( ortholog_many2many ) Rat_ AABR07044362.1 ( ortholog_many2many ) Rat_ RT1-M2 ( ortholog_many2many ) Rat_ RT1-M6-2 ( ortholog_many2many ) Rat_ RT1-M5 ( ortholog_many2many ) Rat_ RT1-M10-1 ( ortholog_many2many ) Rat_ RT1-N2 ( ortholog_many2many )
Ohnologs	NA
Paralogs	MR1, AZGP1, MICA, HFE, MICB, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, CD1A, CD1D, CD1C, RAET1E, ULBP3, ULBP1, CD1E, HLA-C, HLA-A, HLA-G, HLA-F, HLA-E
Tissue	NA
Tissue Specificity	NA
Pharmacological Animal Models	NA
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	1A1M (X-ray 2.30A ) 1A1N (X-ray 2.00A ) 1A1O (X-ray 2.30A ) 1A9B (X-ray 3.20A ) 1A9E (X-ray 2.50A ) 1AGB (X-ray 2.20A ) 1AGC (X-ray 2.10A ) 1AGD (X-ray 2.05A ) 1AGE (X-ray 2.30A ) 1AGF (X-ray 2.20A ) 1CG9 (X-ray 2.70A ) 1E27 (X-ray 2.20A ) 1E28 (X-ray 3.00A ) 1HSA (X-ray 2.10A ) 1JGD (X-ray 1.90A ) 1JGE (X-ray 2.10A ) 1K5N (X-ray 1.09A ) 1M05 (X-ray 1.90A ) 1M6O (X-ray 1.60A ) 1MI5 (X-ray 2.50A ) 1N2R (X-ray 1.70A ) 1OF2 (X-ray 2.20A ) 1OGT (X-ray 1.47A ) 1SYS (X-ray 2.40A ) 1SYV (X-ray 1.70A ) 1UXS (X-ray 1.55A ) 1UXW (X-ray 1.71A ) 1W0V (X-ray 2.27A ) 1W0W (X-ray 2.11A ) 1XH3 (X-ray 1.48A ) 1XR8 (X-ray 2.30A ) 1XR9 (X-ray 1.79A ) 1ZHK (X-ray 1.60A ) 1ZHL (X-ray 1.50A ) 1ZSD (X-ray 1.70A ) 2A83 (X-ray 1.40A ) 2AK4 (X-ray 2.50A ) 2AXF (X-ray 1.80A ) 2AXG (X-ray 2.00A ) 2BSR (X-ray 2.30A ) 2BSS (X-ray 2.00A ) 2BST (X-ray 2.10A ) 2BVO (X-ray 1.65A ) 2BVP (X-ray 1.35A ) 2BVQ (X-ray 2.00A ) 2H6P (X-ray 1.90A ) 2HJL (X-ray 1.50A ) 2NW3 (X-ray 1.70A ) 2NX5 (X-ray 2.70A ) 2RFX (X-ray 2.50A ) 2YPK (X-ray 1.95A ) 2YPL (X-ray 2.40A ) 3B3I (X-ray 1.86A ) 3B6S (X-ray 1.80A ) 3BP4 (X-ray 1.85A ) 3BP7 (X-ray 1.80A ) 3BW9 (X-ray 1.75A ) 3BWA (X-ray 1.30A ) 3C9N (X-ray 1.87A ) 3CZF (X-ray 1.20A ) 3D18 (X-ray 1.74A ) 3DTX (X-ray 2.10A ) 3DX6 (X-ray 1.70A ) 3DX7 (X-ray 1.60A ) 3DX8 (X-ray 2.10A ) 3DXA (X-ray 3.50A ) 3FFC (X-ray 2.80A ) 3HCV (X-ray 1.95A ) 3KPL (X-ray 1.96A ) 3KPM (X-ray 1.60A ) 3KPN (X-ray 2.00A ) 3KPO (X-ray 2.30A ) 3KPP (X-ray 1.90A ) 3KPQ (X-ray 1.84A ) 3KPR (X-ray 2.60A ) 3KPS (X-ray 2.70A ) 3KWW (X-ray 2.18A ) 3KXF (X-ray 3.10A ) 3L3D (X-ray 1.80A ) 3L3G (X-ray 2.10A ) 3L3I (X-ray 1.70A ) 3L3J (X-ray 2.40A ) 3L3K (X-ray 2.60A ) 3LKN (X-ray 2.00A ) 3LKO (X-ray 1.80A ) 3LKP (X-ray 1.80A ) 3LKQ (X-ray 1.80A ) 3LKR (X-ray 2.00A ) 3LKS (X-ray 1.90A ) 3LN4 (X-ray 1.30A ) 3LN5 (X-ray 1.90A ) 3LV3 (X-ray 1.94A ) 3MV7 (X-ray 2.00A ) 3MV8 (X-ray 2.10A ) 3MV9 (X-ray 2.70A ) 3SJV (X-ray 3.10A ) 3SKM (X-ray 1.80A ) 3SKO (X-ray 1.60A ) 3SPV (X-ray 1.30A ) 3UPR (X-ray 2.00A ) 3VCL (X-ray 1.70A ) 3VFS (X-ray 1.85A ) 3VFT (X-ray 1.95A ) 3VFU (X-ray 1.65A ) 3VFV (X-ray 1.55A ) 3VFW (X-ray 2.30A ) 3VH8 (X-ray 1.80A ) 3VRI (X-ray 1.60A ) 3VRJ (X-ray 1.90A ) 3W39 (X-ray 3.10A ) 3WUW (X-ray 2.00A ) 3X11 (X-ray 2.15A ) 3X12 (X-ray 1.80A ) 3X13 (X-ray 1.80A ) 3X14 (X-ray 2.00A ) 4G8G (X-ray 2.40A ) 4G8I (X-ray 1.60A ) 4G9D (X-ray 1.60A ) 4G9F (X-ray 1.90A ) 4JQV (X-ray 1.50A ) 4JQX (X-ray 1.90A ) 4LCY (X-ray 1.60A ) 4LNR (X-ray 2.00A ) 4MJI (X-ray 2.99A ) 4O2C (X-ray 1.80A ) 4O2E (X-ray 1.98A ) 4O2F (X-ray 1.90A ) 4PR5 (X-ray 1.80A ) 4PRN (X-ray 1.65A ) 4QRP (X-ray 2.90A ) 4QRQ (X-ray 1.70A ) 4QRR (X-ray 3.00A ) 4QRS (X-ray 1.40A ) 4QRT (X-ray 1.40A ) 4QRU (X-ray 1.60A ) 4U1H (X-ray 1.59A ) 4U1I (X-ray 1.92A ) 4U1J (X-ray 1.38A ) 4U1K (X-ray 2.09A ) 4U1L (X-ray 2.06A ) 4U1M (X-ray 1.18A ) 4U1N (X-ray 1.77A ) 4U1S (X-ray 1.76A ) 4XXC (X-ray 1.43A ) 5B38 (X-ray 2.30A ) 5B39 (X-ray 2.50A ) 5DEF (X-ray 1.60A ) 5DEG (X-ray 1.83A ) 5EO0 (X-ray 1.70A ) 5EO1 (X-ray 1.85A ) 5IB1 (X-ray 1.91A ) 5IB2 (X-ray 1.44A ) 5IB3 (X-ray 1.91A ) 5IB4 (X-ray 1.95A ) 5IB5 (X-ray 2.49A ) 5IEH (X-ray 1.50A ) 5IEK (X-ray 1.80A ) 5IM7 (X-ray 2.50A ) 5INC (X-ray 2.88A ) 5IND (X-ray 2.13A ) 5T6W (X-ray 1.90A ) 5T6X (X-ray 1.69A ) 5T6Y (X-ray 1.76A ) 5T6Z (X-ray 2.00A ) 5T70 (X-ray 2.10A ) 5TXS (X-ray 1.70A ) 5U98 (X-ray 2.00A ) 5V5L (X-ray 2.00A ) 5V5M (X-ray 2.88A ) 5VUD (X-ray 2.00A ) 5VUE (X-ray 1.80A ) 5VUF (X-ray 1.90A ) 5VWD (X-ray 1.80A ) 5VWF (X-ray 1.80A ) 5VWH (X-ray 1.65A ) 5VWJ (X-ray 2.00A ) 5VZ5 (X-ray 2.59A ) 5WMN (X-ray 1.82A ) 5WMO (X-ray 1.62A ) 5WMP (X-ray 1.60A ) 5WMQ (X-ray 1.40A ) 5WMR (X-ray 1.58A ) 5XOS (X-ray 1.70A ) 5XOT (X-ray 2.79A ) 6AT5 (X-ray 1.50A ) 6AVF (X-ray 2.03A ) 6AVG (X-ray 2.60A ) 6BJ2 (X-ray 3.35A ) 6BJ3 (X-ray 1.90A ) 6BJ8 (X-ray 1.75A ) 6BXP (X-ray 1.45A ) 6BXQ (X-ray 1.58A ) 6D29 (X-ray 1.88A ) 6D2B (X-ray 2.04A ) 6D2R (X-ray 1.83A ) 6D2T (X-ray 1.90A ) 6MT3 (X-ray 1.21A ) 6MT4 (X-ray 1.55A ) 6MT5 (X-ray 1.55A ) 6MT6 (X-ray 1.31A ) 6MTL (X-ray 1.35A ) 6MTM (X-ray 3.00A ) 6P23 (X-ray 1.59A ) 6P27 (X-ray 1.59A ) 6P2C (X-ray 1.40A ) 6P2F (X-ray 1.48A ) 6P2S (X-ray 1.65A ) 6PYJ (X-ray 1.44A ) 6PYL (X-ray 1.52A ) 6PYV (X-ray 1.45A ) 6PYW (X-ray 1.38A ) 6PZ5 (X-ray 1.53A ) 6UJ7 (X-ray 1.90A ) 6UJ8 (X-ray 2.25A ) 6UJ9 (X-ray 2.90A ) 6VMX (X-ray 3.10A ) 7LFZ (X-ray 1.90A ) 7LG0 (X-ray 2.30A ) 7LGD (X-ray 2.88A ) 7LGT (X-ray 1.97A )
DBSNP	rs9266206 rs1050458 rs1050462 rs1131156 rs1131159 rs1131165 rs2596492 rs2596492 rs1131170 rs1050486 rs713031 rs713031 rs9266183 rs1050518 rs1050529 rs41562914 rs9266178 rs1050538 rs145974360 rs141484466 rs1131201 rs1131202 rs1071816 rs1071816 rs1071816 rs1131204 rs1071817 rs1131213 rs1131215 rs41553715 rs1131217 rs1050388 rs1131223 rs1131223 rs3180379 rs3180380 rs41559314 rs12721827 rs12721829 rs1071652 rs1140412 rs1071652 rs151341218 rs151341218 rs1131112 rs1131112 rs1050379 rs709055 rs709055 rs9266150 rs4997052 rs796516815 rs4997052 rs1050654 rs41541519 rs12697943 rs41551018 rs151341293 rs1203316963 rs697742 rs9266144 rs1050683 rs41543920 rs796093434 rs796093434 rs1050692 rs1050696 rs1131275 rs1131279 rs1131285 rs1050341 rs1050723 rs41545916 rs2308488 rs41542113 rs1611623 rs41541515 rs2308500 rs1131500 rs1051488 rs41548215 rs2308655
Subcellular location [CC]	Cell membrane {ECO:0000269\|PubMed:25480565, ECO:0000269\|PubMed:26439010, ECO:0000269\|PubMed:9620674}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305\|PubMed:9620674}; Single-pass type I membrane protein {ECO:0000255}.
Mouse PG classification	NA
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