| Gene Information | |
|---|---|
| Gene Name | NLRP5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1200 |
| Protein Names | NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog) (Maternal Antigen that Embryos Require) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000171487 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P59047 |
| Gene Card | NLRP5 |
| Uniprot ID | P59047 |
| Pfam | PF13516; PF05729; PF17776; PF17779; PF02758 |
| In ASD | no |
| Allosteric Prediction | no (-0.983456399) |
| Ortholog in Animals | Alpaca_ NLRP5 ( ortholog_one2one ) Dog_ NLRP5 ( ortholog_one2one ) Macaque_ NLRP5 ( ortholog_one2one ) Mouse_ Nlrp5 ( ortholog_one2one ) Pig_ NLRP5 ( ortholog_one2one ) Rat_ Nlrp5 ( ortholog_one2many ) Rabbit_ NLRP5 ( ortholog_one2one ) |
| Ohnologs | NLRC3 |
| Paralogs | NLRP9, NLRC5, NLRP14, NLRP7, NLRP4, CIITA, NOD1, NLRP8, NLRP10, NLRP3, NLRP6, NLRP11, NLRP2, PYDC2, NLRC3, NLRX1, NLRP12, NLRP13, NLRP1, NOD2 |
| Tissue | NA |
| Tissue Specificity | Expressed in cumulus cells (at protein level) (PubMed:19542546). Highly abundant in oocytes and early embryos, however poorly expressed in somatic tissues such as the liver and spinal cord (PubMed:11925379, PubMed:30877238). {ECO:0000269|PubMed:11925379, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:30877238}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs753824534 rs752189640 rs758399773 rs746147069 rs763987829 rs471979 rs199475775 rs754695863 rs752560793 rs34395092 rs373407667 rs17713875 rs370837790 rs200446614 rs769920247 rs16986899 rs3103057 rs1381057964 rs12462795 rs10409555 rs36118060 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000269|PubMed:19192343}. Mitochondrion {ECO:0000269|PubMed:19192343}. Nucleus, nucleolus {ECO:0000269|PubMed:19192343, ECO:0000269|PubMed:25542835}. Cytoplasm {ECO:0000269|PubMed:19192343, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:25542835}. Golgi apparatus {ECO:0000269|PubMed:19192343}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |