| Gene Information | |
|---|---|
| Gene Name | RAC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 192 |
| Protein Names | Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000169750 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P60763 |
| Gene Card | RAC3 |
| Uniprot ID | P60763 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.233714272) |
| Ortholog in Animals | Alpaca_ RAC3 ( ortholog_one2one ) Dog_ RAC3 ( ortholog_one2one ) GuineaPig_ RAC3 ( ortholog_one2one ) Macaque_ RAC3 ( ortholog_one2one ) Mouse_ Rac3 ( ortholog_one2one ) Pig_ RAC3 ( ortholog_one2one ) Rat_ Rac3 ( ortholog_one2one ) |
| Ohnologs | RAC2, RAC1 |
| Paralogs | RAC1, RND1, CDC42, RHOT1, RHOBTB3, RHOT2, RHOJ, RHOA, RHOC, RHOB, RHOV, RHOQ, RHOBTB2, RND2, RND3, RHOD, RHOF, RHOG, RHOU, RAC2, RHOBTB1, RHOH |
| Tissue | NA |
| Tissue Specificity | Highest levels in brain, also detected in heart, placenta and pancreas. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001223(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2C2H (X-ray 1.85A ) 2G0N (X-ray 1.90A ) 2IC5 (X-ray 1.90A ) 2OV2 (X-ray 2.10A ) 2QME (X-ray 1.75A ) 6TM1 (X-ray 3.71A ) |
| DBSNP | rs1568018697 rs1379395211 rs1568018920 rs1064797229 |
| Subcellular location [CC] | Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Note=Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery. |
| Mouse PG classification | NA |
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