Gene Information
Gene NameNEDD4
OrganismHomo sapiens (Human)
Gene Length1319
Protein NamesE3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000069869 )
Evolutionary StageEukaryota
AlphaFoldDBP46934
Gene CardNEDD4
Uniprot IDP46934
PfamPF00632; PF00397
In ASDno
Allosteric Predictionyes (0.661051259)
Ortholog in AnimalsAlpaca_ NEDD4 ( ortholog_one2one )
Dog_ NEDD4 ( ortholog_one2one )
GuineaPig_ NEDD4 ( ortholog_one2one )
Macaque_ NEDD4 ( ortholog_one2one )
Mouse_ Nedd4 ( ortholog_one2one )
Pig_ NEDD4 ( ortholog_one2one )
Rat_ Nedd4 ( ortholog_one2one )
Rabbit_ NEDD4 ( ortholog_one2one )
OhnologsNEDD4L
ParalogsHERC4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HERC2, HECW2, HERC3, WWP1, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, HECW1, WWP2, TRIP12, HERC5, HERC6
Tissueartery
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.039455(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2KPZ  (NMR  -  )  2KQ0  (NMR  -  )  2M3O  (NMR  -  )  2XBB  (X-ray  2.68A  )  2XBF  (X-ray  2.50A  )  3B7Y  (X-ray  1.80A  )  4BBN  (X-ray  2.51A  )  4BE8  (X-ray  3.00A  )  4N7F  (X-ray  1.10A  )  4N7H  (X-ray  1.70A  )  5AHT  (NMR  -  )  5C7J  (X-ray  3.00A  )  5C91  (X-ray  2.44A  ) 
DBSNP rs1912403  rs2303580  rs2303579 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:11342538}. Nucleus {ECO:0000269|PubMed:11342538}. Cell membrane {ECO:0000250|UniProtKB:P46935};
Peripheral membrane protein {ECO:0000250|UniProtKB:P46935}. Note=Predominantly cytoplasmic but also located in the nucleus (PubMed:11342538). Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1 (PubMed:18819914). {ECO:0000250|UniProtKB:P46935, ECO:0000269|PubMed:11342538, ECO:0000269|PubMed:18819914}.
Mouse PG classificationNA
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