| Gene Information | |
|---|---|
| Gene Name | HTR3B |
| Organism | Homo sapiens (Human) |
| Gene Length | 441 |
| Protein Names | 5-hydroxytryptamine receptor 3B (5-HT3-B) (5-HT3B) (Serotonin receptor 3B) |
| Target Name | 5-ht 3b receptor |
| Target Type | Discontinued target |
| Gene Age | 645 ( ENSG00000149305 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95264 |
| Gene Card | HTR3B |
| Uniprot ID | O95264 |
| Pfam | PF02931; PF02932 |
| In ASD | no |
| Allosteric Prediction | yes (0.650420737) |
| Ortholog in Animals | Alpaca_ HTR3B ( ortholog_one2one ) Dog_ HTR3B ( ortholog_one2one ) GuineaPig_ HTR3B ( ortholog_one2one ) Macaque_ HTR3B ( ortholog_one2one ) Mouse_ Htr3b ( ortholog_one2one ) Pig_ HTR3B ( ortholog_one2one ) Rat_ Htr3b ( ortholog_one2one ) Rabbit_ HTR3B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, GLRA2, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB |
| Tissue | NA |
| Tissue Specificity | Expressed in the brain cortex, in the caudate nucleus, the hippocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta. {ECO:0000269|PubMed:10521471, ECO:0000269|PubMed:9950429}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1176744 rs34550504 rs72466469 rs17116138 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21138434}; Multi-pass membrane protein {ECO:0000269|PubMed:21138434}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. |
| Mouse PG classification | NA |
| click here to return to the previous page | |