| Gene Information | |
|---|---|
| Gene Name | PUM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1066 |
| Protein Names | Pumilio homolog 2 (Pumilio-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000055917 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TB72 |
| Gene Card | PUM2 |
| Uniprot ID | Q8TB72 |
| Pfam | PF00806 |
| In ASD | no |
| Allosteric Prediction | no (-0.852730203) |
| Ortholog in Animals | Alpaca_ PUM2 ( ortholog_one2one ) Dog_ PUM2 ( ortholog_one2one ) GuineaPig_ PUM2 ( ortholog_one2one ) Macaque_ PUM2 ( ortholog_one2one ) Mouse_ Pum2 ( ortholog_one2one ) Pig_ PUM2 ( ortholog_one2one ) Rat_ Pum2 ( ortholog_one2one ) Rabbit_ PUM2 ( ortholog_one2one ) |
| Ohnologs | PUM1 |
| Paralogs | PUM1 |
| Tissue | NA |
| Tissue Specificity | Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested. {ECO:0000269|PubMed:12459267, ECO:0000269|PubMed:12511597, ECO:0000269|PubMed:19168546}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.014286(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3Q0Q (X-ray 2.00A ) 3Q0R (X-ray 2.00A ) 3Q0S (X-ray 2.00A ) |
| DBSNP | rs34032508 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305|PubMed:19168546}. Cytoplasmic granule {ECO:0000269|PubMed:25340845}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19168546}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules. Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells. {ECO:0000269|PubMed:25340845}. |
| Mouse PG classification | NA |
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