| Gene Information | |
|---|---|
| Gene Name | ATP5F1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 553 |
| Protein Names | ATP synthase subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000152234 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P25705 |
| Gene Card | ATP5F1A |
| Uniprot ID | P25705 |
| Pfam | PF00006; PF00306; PF02874 |
| In ASD | no |
| Allosteric Prediction | yes (0.906904362) |
| Ortholog in Animals | Alpaca_ ATP5F1A ( ortholog_one2one ) Dog_ ATP5F1A ( ortholog_one2many ) GuineaPig_ ATP5F1A ( ortholog_one2one ) Macaque_ ATP5F1A ( ortholog_one2one ) Mouse_ Atp5a1 ( ortholog_one2one ) Pig_ ATP5F1A ( ortholog_one2one ) Rat_ Atp5f1a ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ATP5F1B, ATP6V1A, ATP6V1B1, ATP6V1B2 |
| Tissue | NA |
| Tissue Specificity | Fetal lung, heart, liver, gut and kidney. Expressed at higher levels in the fetal brain, retina and spinal cord. {ECO:0000269|PubMed:8428659}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.021652(Rat);0.262534(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2228437 rs587777788 rs587776960 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:30146159}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P19483}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19483}; Matrix side {ECO:0000250|UniProtKB:P19483}. Cell membrane {ECO:0000269|PubMed:10077593}; Peripheral membrane protein {ECO:0000269|PubMed:10077593}; Extracellular side {ECO:0000269|PubMed:10077593}. Note=Colocalizes with HRG on the cell surface of T-cells (PubMed:19285951). {ECO:0000269|PubMed:19285951}. |
| Mouse PG classification | NA |
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