| Gene Information | |
|---|---|
| Gene Name | ATP4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1035 |
| Protein Names | Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) |
| Target Name | potassium-transporting atpase alpha chain 1 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000105675 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P20648 |
| Gene Card | ATP4A |
| Uniprot ID | P20648 |
| Pfam | PF00689; PF00690; PF09040 |
| In ASD | no |
| Allosteric Prediction | yes (1.033841619) |
| Ortholog in Animals | Alpaca_ ATP4A ( ortholog_one2one ) Dog_ ATP4A ( ortholog_one2one ) GuineaPig_ ATP4A ( ortholog_one2one ) Macaque_ ATP4A ( ortholog_one2one ) Mouse_ Atp4a ( ortholog_one2one ) Pig_ ATP4A ( ortholog_one2one ) Rat_ Atp4a ( ortholog_one2one ) Rabbit_ ATP4A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP2B2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP2C1, ATP13A1 |
| Tissue | stomach, adrenal.gland |
| Tissue Specificity | Expressed in gastric parietal cells (at protein level). {ECO:0000269|PubMed:24188822}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2733743 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:24188822}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the apical canalicular membrane of parietal cells (PubMed:24188822). Localized in the apical canalicular membrane of parietal cells (PubMed:24188822). {ECO:0000269|PubMed:24188822}. |
| Mouse PG classification | NA |
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