| Gene Information | |
|---|---|
| Gene Name | ATP2C2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 946 |
| Protein Names | Calcium-transporting ATPase type 2C member 2 (ATPase 2C2) (EC 7.2.2.10) (Ca(2+)/Mn(2+)-ATPase 2C2) (Secretory pathway Ca(2+)-transporting ATPase type 2) (SPCA2) |
| Target Name | calcium transporting atpases |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000064270 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O75185 |
| Gene Card | ATP2C2 |
| Uniprot ID | O75185 |
| Pfam | PF00689; PF00690 |
| In ASD | no |
| Allosteric Prediction | no (-0.607649198) |
| Ortholog in Animals | Alpaca_ ATP2C2 ( ortholog_one2one ) Dog_ ATP2C2 ( ortholog_one2one ) GuineaPig_ ATP2C2 ( ortholog_one2one ) Macaque_ ATP2C2 ( ortholog_one2one ) Mouse_ Atp2c2 ( ortholog_one2one ) Pig_ ATP2C2 ( ortholog_one2one ) Rat_ Atp2c2 ( ortholog_one2one ) |
| Ohnologs | ATP2C1 |
| Paralogs | ATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP2B2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP2C1, ATP13A1 |
| Tissue | colon, lung |
| Tissue Specificity | Highly expressed in the gastrointestinal and respiratory tracts, prostate, thyroid, salivary, and mammary glands (PubMed:15831496). Expressed in colon epithelial cells (at protein level). Expressed in brain and testis (at protein level) (PubMed:15677451). {ECO:0000269|PubMed:15677451, ECO:0000269|PubMed:15831496}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs247818 rs2303853 rs247897 rs62640926 rs16973859 |
| Subcellular location [CC] | Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15831496}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:20887894}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:A7L9Z8}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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