| Gene Information | |
|---|---|
| Gene Name | ATP2B4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1241 |
| Protein Names | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) |
| Target Name | calcium transporting atpases |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000058668 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P23634 |
| Gene Card | ATP2B4 |
| Uniprot ID | P23634 |
| Pfam | PF12424; PF00689; PF00690 |
| In ASD | no |
| Allosteric Prediction | yes (0.548606564) |
| Ortholog in Animals | Alpaca_ ATP2B4 ( ortholog_one2one ) Dog_ ATP2B4 ( ortholog_one2one ) GuineaPig_ ATP2B4 ( ortholog_one2one ) Macaque_ ATP2B4 ( ortholog_one2one ) Mouse_ Atp2b4 ( ortholog_one2one ) Pig_ ATP2B4 ( ortholog_one2one ) Rat_ Atp2b4 ( ortholog_one2one ) |
| Ohnologs | ATP2B3, ATP2B1, ATP2B2 |
| Paralogs | ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP2B2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP2C1, ATP13A1 |
| Tissue | NA |
| Tissue Specificity | Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex. {ECO:0000269|PubMed:1531651}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1CFF (NMR - ) 2KNE (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:2137451}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q6Q477}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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