Gene Information
Gene NameATP2B3
OrganismHomo sapiens (Human)
Gene Length1220
Protein NamesPlasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3)
Target Namecalcium transporting atpases
Target TypeNA
Gene Age>4290 ( ENSG00000067842 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ16720
Gene CardATP2B3
Uniprot IDQ16720
PfamPF12424; PF00689; PF00690
In ASDno
Allosteric Predictionyes (0.571882882)
Ortholog in AnimalsAlpaca_ ATP2B3 ( ortholog_one2one )
Dog_ ATP2B3 ( ortholog_one2one )
GuineaPig_ ATP2B3 ( ortholog_one2one )
Macaque_ ATP2B3 ( ortholog_one2one )
Mouse_ Atp2b3 ( ortholog_one2one )
Pig_ ATP2B3 ( ortholog_one2one )
Rat_ Atp2b3 ( ortholog_one2one )
Rabbit_ ATP2B3 ( ortholog_one2one )
OhnologsATP2B4, ATP2B1, ATP2B2
ParalogsATP2B4, ATP13A3, ATP7A, ATP2A3, ATP1A3, ATP13A2, ATP2B2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP2C1, ATP13A1
Tissueadrenal.gland, brain, cerebellar.hemisphere, cerebellum, cerebral.cortex, nucleus.accumbens
Tissue SpecificityHighly expressed in the cerebellum (PubMed:8187550). Expressed in adrenal glands (PubMed:27035656). {ECO:0000269|PubMed:27035656, ECO:0000269|PubMed:8187550}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs2269409  rs397514619 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:18029012, ECO:0000269|PubMed:25953895};
Multi-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q64568};
Multi-pass membrane protein {ECO:0000255}. Note=Localized at parallel fiber terminals. {ECO:0000250|UniProtKB:Q64568}.
Mouse PG classificationNA
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