Gene Information
Gene NameATP2B2
OrganismHomo sapiens (Human)
Gene Length1241
Protein NamesPlasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)
Target Namecalcium transporting atpases
Target TypeNA
Gene Age886 ( ENSG00000157087 )
Evolutionary StageEuk+Bac
AlphaFoldDBP23634
Gene CardATP2B4
Uniprot IDP23634
PfamPF12424; PF00689; PF00690
In ASDno
Allosteric Predictionyes (0.531644826)
Ortholog in AnimalsAlpaca_ ATP2B2 ( ortholog_one2one )
Dog_ ATP2B2 ( ortholog_one2one )
GuineaPig_ ATP2B2 ( ortholog_one2one )
Macaque_ ATP2B2 ( ortholog_one2one )
Mouse_ Atp2b2 ( ortholog_one2one )
Pig_ ATP2B2 ( ortholog_one2one )
Rat_ Atp2b2 ( ortholog_one2one )
Rabbit_ ATP2B2 ( ortholog_one2one )
OhnologsATP2B3, ATP2B1, ATP2B4
ParalogsATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP2C1, ATP13A1
Tissuebrain, cerebral.cortex, cerebellar.hemisphere, cerebellum
Tissue SpecificityIsoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex. {ECO:0000269|PubMed:1531651}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1CFF  (NMR  -  )  2KNE  (NMR  -  ) 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:2137451};
Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q6Q477};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationNA
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