| Gene Information | |
|---|---|
| Gene Name | ATP2B2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1243 |
| Protein Names | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) |
| Target Name | calcium transporting atpases |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000157087 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q01814 |
| Gene Card | ATP2B2 |
| Uniprot ID | Q01814 |
| Pfam | PF12424; PF00689; PF00690 |
| In ASD | no |
| Allosteric Prediction | yes (0.531644826) |
| Ortholog in Animals | Alpaca_ ATP2B2 ( ortholog_one2one ) Dog_ ATP2B2 ( ortholog_one2one ) GuineaPig_ ATP2B2 ( ortholog_one2one ) Macaque_ ATP2B2 ( ortholog_one2one ) Mouse_ Atp2b2 ( ortholog_one2one ) Pig_ ATP2B2 ( ortholog_one2one ) Rat_ Atp2b2 ( ortholog_one2one ) Rabbit_ ATP2B2 ( ortholog_one2one ) |
| Ohnologs | ATP2B3, ATP2B1, ATP2B4 |
| Paralogs | ATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP2C1, ATP13A1 |
| Tissue | brain, cerebral.cortex, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle. {ECO:0000269|PubMed:8245032}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17234811}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q9R0K7}.; [Isoform WA]: Apical cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}.; [Isoform WB]: Apical cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}.; [Isoform XB]: Basolateral cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}.; [Isoform ZA]: Basolateral cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}.; [Isoform ZB]: Basolateral cell membrane {ECO:0000269|PubMed:12624087}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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