| Gene Information | |
|---|---|
| Gene Name | ATP2B1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1220 |
| Protein Names | Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1) |
| Target Name | plasma membrane calcium-transporting atpase |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000070961 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P20020 |
| Gene Card | ATP2B1 |
| Uniprot ID | P20020 |
| Pfam | PF12424; PF00689; PF00690 |
| In ASD | no |
| Allosteric Prediction | yes (0.367536116) |
| Ortholog in Animals | Alpaca_ ATP2B1 ( ortholog_one2one ) Dog_ ATP2B1 ( ortholog_one2one ) GuineaPig_ ATP2B1 ( ortholog_one2one ) Macaque_ ATP2B1 ( ortholog_one2one ) Mouse_ Atp2b1 ( ortholog_one2one ) Pig_ ATP2B1 ( ortholog_one2one ) Rat_ Atp2b1 ( ortholog_one2one ) Rabbit_ ATP2B1 ( ortholog_one2one ) |
| Ohnologs | ATP2B3, ATP2B4, ATP2B2 |
| Paralogs | ATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP2B2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP2C1, ATP13A1 |
| Tissue | NA |
| Tissue Specificity | Isoform B: Ubiquitously expressed. Isoform C: Found in brain cortex, skeletal muscle and heart muscle. Isoform D: Has only been found in fetal skeletal muscle. Isoform K: Found in small intestine and liver. Abundantly expressed in the endometrial epithelial cells and glandular epithelial cells in early-proliferative phase and early-secretory phases (PubMed:21400627). {ECO:0000269|PubMed:21400627}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6A69 (EM 4.11A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18029012}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:G5E829}. Synapse {ECO:0000250|UniProtKB:G5E829}. Presynaptic cell membrane {ECO:0000250|UniProtKB:G5E829}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:G5E829}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with SV2A in photoreceptor synaptic terminals. Colocalizes with NPTN to the immunological synapse. Colocalizes with EPB41 to the basolateral membrane in enterocyte. Preferentially sorted to recycling synaptic vesicles. {ECO:0000250|UniProtKB:G5E829}. |
| Mouse PG classification | NA |
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