Gene Information
Gene NameATP2A2
OrganismHomo sapiens (Human)
Gene Length1042
Protein NamesSarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
Target Namecalcium transporting atpases
Target TypeNA
Gene Age>4290 ( ENSG00000174437 )
Evolutionary StageEukaryota
AlphaFoldDBP16615
Gene CardATP2A2
Uniprot IDP16615
PfamPF00689; PF00690
In ASDyes
Allosteric Predictionyes (1.469503806)
Ortholog in AnimalsAlpaca_ ATP2A2 ( ortholog_one2one )
Dog_ ATP2A2 ( ortholog_one2one )
GuineaPig_ ATP2A2 ( ortholog_one2one )
Macaque_ ATP2A2 ( ortholog_one2one )
Mouse_ Atp2a2 ( ortholog_one2one )
Pig_ ATP2A2 ( ortholog_one2one )
Rat_ Atp2a2 ( ortholog_one2one )
Rabbit_ ATP2A2 ( ortholog_one2one )
OhnologsATP2A3, ATP2A1
ParalogsATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP2B2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP4A, ATP2C1, ATP13A1
TissueNA
Tissue SpecificityIsoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart. {ECO:0000269|PubMed:10441324, ECO:0000269|PubMed:12659872, ECO:0000269|PubMed:16402920}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5ZTF  (X-ray  3.45A  )  6JJU  (X-ray  3.20A  )  6LLE  (EM  2.90A  )  6LLY  (EM  2.80A  )  6LN5  (EM  2.80A  )  6LN6  (EM  2.90A  )  6LN7  (EM  2.80A  )  6LN8  (EM  3.10A  )  6LN9  (EM  3.40A  )  7BT2  (X-ray  3.00A  )  7E7S  (EM  3.30A  ) 
DBSNP rs28929478  rs121912738  rs121912733  rs121912734  rs121912737  rs121912732  rs121912736 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O55143};
Multi-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:12804600};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationHPG
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