| Gene Information | |
|---|---|
| Gene Name | ATP2A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1001 |
| Protein Names | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) |
| Target Name | calcium transporting atpases |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000196296 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O14983 |
| Gene Card | ATP2A1 |
| Uniprot ID | O14983 |
| Pfam | PF00689; PF00690 |
| In ASD | no |
| Allosteric Prediction | yes (0.652787825) |
| Ortholog in Animals | Alpaca_ ATP2A1 ( ortholog_one2one ) Dog_ ATP2A1 ( ortholog_one2one ) GuineaPig_ ATP2A1 ( ortholog_one2one ) Macaque_ ATP2A1 ( ortholog_one2one ) Mouse_ Atp2a1 ( ortholog_one2one ) Pig_ ATP2A1 ( ortholog_one2one ) Rat_ AABR07005775.1 ( ortholog_one2one ) Rabbit_ ATP2A1 ( ortholog_one2one ) |
| Ohnologs | ATP2A3, ATP2A2 |
| Paralogs | ATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP2B2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A2, ATP4A, ATP2C1, ATP13A1 |
| Tissue | esophagus, skeletal.muscle, artery |
| Tissue Specificity | Skeletal muscle, fast twitch muscle (type II) fibers. {ECO:0000269|PubMed:8825625}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs121918115 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04191}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04191}. |
| Mouse PG classification | NA |
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