| Gene Information | |
|---|---|
| Gene Name | ATP1A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1023 |
| Protein Names | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) |
| Target Name | sodium/potassium transporting atpase subunits |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000163399 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P05023 |
| Gene Card | ATP1A1 |
| Uniprot ID | P05023 |
| Pfam | PF00689; PF00690 |
| In ASD | no |
| Allosteric Prediction | yes (1.464656029) |
| Ortholog in Animals | Alpaca_ ATP1A1 ( ortholog_one2one ) Dog_ ATP1A1 ( ortholog_one2one ) GuineaPig_ ATP1A1 ( ortholog_one2one ) Macaque_ ATP1A1 ( ortholog_one2one ) Mouse_ Atp1a1 ( ortholog_one2one ) Pig_ ATP1A1 ( ortholog_one2one ) Rat_ Atp1a1 ( ortholog_one2one ) Rabbit_ ATP1A1 ( ortholog_one2one ) |
| Ohnologs | ATP1A2, ATP1A4 |
| Paralogs | ATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP2B2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP2C1, ATP13A1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.009524(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7E1Z (EM 3.20A ) 7E20 (EM 2.70A ) 7E21 (EM 2.90A ) |
| DBSNP | rs12564026 rs1553190285 rs1557785503 rs1553192086 rs1553192091 rs1553192091 rs1553192783 rs781629728 |
| Subcellular location [CC] | Basolateral cell membrane {ECO:0000250|UniProtKB:P06685}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P06685}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}. |
| Mouse PG classification | NA |
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