| Gene Information | |
|---|---|
| Gene Name | ATL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 541 |
| Protein Names | Atlastin-3 (EC 3.6.5.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000184743 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6DD88 |
| Gene Card | ATL3 |
| Uniprot ID | Q6DD88 |
| Pfam | PF02263; PF02841 |
| In ASD | no |
| Allosteric Prediction | no (-0.882149894) |
| Ortholog in Animals | Alpaca_ ATL3 ( ortholog_one2one ) Dog_ ATL3 ( ortholog_one2one ) GuineaPig_ ATL3 ( ortholog_one2one ) Macaque_ ATL3 ( ortholog_one2one ) Mouse_ Atl3 ( ortholog_one2one ) Pig_ ATL3 ( ortholog_one2one ) Rat_ Atl3 ( ortholog_one2one ) Rabbit_ ATL3 ( ortholog_one2one ) |
| Ohnologs | ATL1, ATL2 |
| Paralogs | ATL1, GBP5, ATL2, GBP7, GBP2, GBP6, GBP1, RNF112, GBP4, GBP3 |
| Tissue | NA |
| Tissue Specificity | Expressed in the central nervous system and in dorsal root ganglia neurons. Expressed in peripheral tissues (at protein level). {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:24459106}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5VGR (X-ray 2.10A ) 6XJO (X-ray 2.10A ) |
| DBSNP | rs587777108 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:24459106, ECO:0000269|PubMed:27619977}; Multi-pass membrane protein {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:24459106}. Note=Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network. {ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:24459106, ECO:0000269|PubMed:27619977}. |
| Mouse PG classification | NA |
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