| Gene Information | |
|---|---|
| Gene Name | GZMB |
| Organism | Homo sapiens (Human) |
| Gene Length | 247 |
| Protein Names | Granzyme B (EC 3.4.21.79) (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (T-cell serine protease 1-3E) |
| Target Name | granzyme b |
| Target Type | Literature-reported target |
| Gene Age | 544 ( ENSG00000100453 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P10144 |
| Gene Card | GZMB |
| Uniprot ID | P10144 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.508578935) |
| Ortholog in Animals | Alpaca_ GZMB ( ortholog_one2one ) Dog_ GZMB ( ortholog_one2one ) Macaque_ GZMB ( ortholog_one2one ) Pig_ GZMB ( ortholog_one2one ) |
| Ohnologs | GZMA |
| Paralogs | GZMH, CTSG, CMA1, AZU1, KLK13, KLK6 |
| Tissue | whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1FQ3 (X-ray 3.10A ) 1IAU (X-ray 2.00A ) |
| DBSNP | rs8192917 rs11539752 rs2236338 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:8258716}. Cytolytic granule {ECO:0000269|PubMed:1985927, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:8258716}. Note=Delivered into the target cell by perforin (PubMed:20038786). {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:8258716}. |
| Mouse PG classification | NA |
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