| Gene Information | |
|---|---|
| Gene Name | ATIC |
| Organism | Homo sapiens (Human) |
| Gene Length | 592 |
| Protein Names | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] |
| Target Name | bifunctional purine biosynthesis protein purh |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000138363 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P31939 |
| Gene Card | ATIC |
| Uniprot ID | P31939 |
| Pfam | PF01808; PF02142 |
| In ASD | no |
| Allosteric Prediction | yes (1.284752395) |
| Ortholog in Animals | Alpaca_ ATIC ( ortholog_one2one ) Dog_ ATIC ( ortholog_one2many ) GuineaPig_ ATIC ( ortholog_one2one ) Macaque_ ATIC ( ortholog_one2one ) Mouse_ Atic ( ortholog_one2one ) Pig_ ATIC ( ortholog_one2one ) Rat_ Atic ( ortholog_one2one ) Rabbit_ ATIC ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Present in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas. {ECO:0000269|PubMed:9378707}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1P4R (X-ray 2.55A ) 1PKX (X-ray 1.90A ) 1PL0 (X-ray 2.60A ) 5UY8 (X-ray 2.39A ) 5UZ0 (X-ray 1.79A ) |
| DBSNP | rs2372536 rs121434478 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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