| Gene Information | |
|---|---|
| Gene Name | ATG7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 703 |
| Protein Names | Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000197548 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95352 |
| Gene Card | ATG7 |
| Uniprot ID | O95352 |
| Pfam | PF16420; PF00899 |
| In ASD | no |
| Allosteric Prediction | yes (0.501061177) |
| Ortholog in Animals | Alpaca_ ATG7 ( ortholog_one2one ) Dog_ ATG7 ( ortholog_one2one ) GuineaPig_ ATG7 ( ortholog_one2one ) Macaque_ ATG7 ( ortholog_one2one ) Mouse_ Atg7 ( ortholog_one2one ) Pig_ ATG7 ( ortholog_one2one ) Rat_ Atg7 ( ortholog_one2one ) Rabbit_ ATG7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UBA7, UBA3, NAE1, UBA6, UBA2, UBA1, UBA5, MOCS3, SAE1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. {ECO:0000269|PubMed:11890701}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs36117895 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}. |
| Mouse PG classification | NA |
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